What is the primary impairment seen in Duchenne Muscular Dystrophy?

Duchenne Muscular Dystrophy (DMD) is characterized primarily by insidious muscle weakness that gradually worsens over time. This condition is caused by a genetic mutation that affects the production of dystrophin, a protein essential for muscle function. As dystrophin production is impaired, muscle fibers become more susceptible to damage, leading to progressive weakening.

The onset of weakness is typically subtle, beginning in early childhood, and it affects the proximal muscles first, such as those in the hips, pelvis, and shoulders. As the disease progresses, weakness spreads to other muscle groups, ultimately impacting mobility and physical function significantly.

Understanding this primary feature of DMD highlights the importance of early recognition and intervention. Management of the disease often focuses on preserving muscle function and mobility for as long as possible, which is critical given the progressive nature of muscle weakness in this condition.

The other potential impairments mentioned, such as severe joint contractures, rapid onset paralysis, and chronic pain syndromes, can occur as secondary effects due to the muscle weakness, but they are not the primary impairment specifically associated with Duchenne Muscular Dystrophy.